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Lund University

Cell Death: Home

Literature and resources related to cell death
Welcome to the topic guide on cell death!


This guide provides literature references and links to other resources for those interested in cell death and its different forms, such as apoptosis, necrosis and lysosome-dependent cell death.


Cell death overview

Cell Survival and Cell Death. Baehrecke EH, Green DR, Kornbluth S, Salvesen GS (eds). Cold Spring Harbor Perspectives in Biology. Cold Spring Harbor Laboratory Press, 2013. ISBN: 978-1-936113-31-6


Green DR. Means to an End: Apoptosis and Other Cell Death Mechanisms. Cold Spring Harbor Laboratory Press, 2011. ISBN: 978-0-879698-87-4


Green DR, Llambi F. Cell Death Signaling. Cold Spring Harb Perspect Biol 2015; 7. doi: 10.1101/cshperspect.a006080.


Plant Programmed Cell Death, Gunawardena AN, McCabe P (eds). Springer International Publishing: Switzerland, 2015. ISBN: 978-3-319-21033-9




Best-practice guides for cell death classification

Galluzzi L, Vitale I, Aaronson SA et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 2018; 25: 486-541. doi: 10.1038/s41418-017-0012-4.


Carmona-Gutierrez D, Bauer MA, Zimmermann A et al. Guidelines and recommendations on yeast cell death nomenclature. Microb Cell 2018; 5: 4-31. doi: 10.15698/mic2018.01.607.


Galluzzi L, Bravo-San Pedro JM, Vitale I et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ 2015; 22: 58-73. doi: 10.1038/cdd.2014.137.


Galluzzi L, Vitale I, Abrams JM et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012; 19: 107-120. doi: 10.1038/cdd.2011.96.


Kroemer G, Galluzzi L, Vandenabeele P et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009; 16: 3-11. doi: 10.1038/cdd.2008.150.



Cell death methodology

Regulated Cell Death Part A: Apoptotic Mechanisms, Ashkenazi A, Yuan J, Wells J (eds). Methods in Enzymology vol. 544. Elsevier 2014. ISBN: 978-0-12-417158-9


Regulated Cell Death Part B: Necroptotic, Autophagic and other Non-apoptotic Mechanisms, Ashkenazi A, Yuan J, Wells J (eds). Methods in Enzymology vol. 454. Elsevier, 2014. ISBN: 978-0-12-801430-1


Kepp O, Senovilla L, Vitale I et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology 2014; 3: e955691. doi: 10.4161/21624011.2014.955691.


Mery B, Guy JB, Vallard A et al. In Vitro Cell Death Determination for Drug Discovery: A Landscape Review of Real Issues. J Cell Death 2017; 10: 1179670717691251. doi: 10.1177/1179670717691251.


Kepp O, Galluzzi L, Lipinski M et al. Cell death assays for drug discovery. Nat Rev Drug Discov 2011; 10: 221-237. doi: 10.1038/nrd3373.


Vanden Berghe T, Grootjans S, Goossens V et al. Determination of apoptotic and necrotic cell death in vitro and in vivo. Methods 2013; 61: 117-129. doi: 10.1016/j.ymeth.2013.02.011.


Galluzzi L, Aaronson SA, Abrams J et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ 2009; 16: 1093-1107. doi: 10.1038/cdd.2009.44.



Apoptosis, Bcl-2 family, caspases and mitochondria

Green DR. Apoptosis: Physiology and Pathology. Cambridge University Press, 2011. ISBN: 9780521886567


Kale J, Osterlund EJ, Andrews DW. BCL-2 family proteins: changing partners in the dance towards death. Cell Death Differ 2018; 25: 65-80. doi: 10.1038/cdd.2017.186.


Kalkavan H, Green DR. MOMP, cell suicide as a BCL-2 family business. Cell Death Differ 2018; 25: 46-55. doi: 10.1038/cdd.2017.179.


Aubrey BJ, Kelly GL, Janic A et al. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ 2018; 25: 104-113. doi: 10.1038/cdd.2017.169.


Strasser A, Vaux DL. Viewing BCL2 and cell death control from an evolutionary perspective. Cell Death Differ 2018; 25: 13-20. doi: 10.1038/cdd.2017.145.


Green DR. Cancer and Apoptosis: Who Is Built to Last? Cancer Cell 2017; 31: 2-4. doi: 10.1016/j.ccell.2016.12.007.


Schenk RL, Strasser A, Dewson G. BCL-2: Long and winding path from discovery to therapeutic target. Biochem Biophys Res Commun 2017; 482: 459-469. doi: 10.1016/j.bbrc.2016.10.100.


Tummers B, Green DR. Caspase-8: regulating life and death. Immunol Rev 2017; 277: 76-89. doi: 10.1111/imr.12541.


Julien O, Wells JA. Caspases and their substrates. Cell Death Differ 2017; 24: 1380-1389. doi: 10.1038/cdd.2017.44.


Izzo V, Bravo-San Pedro JM, Sica V et al. Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties. Trends Cell Biol 2016; 26: 655-667. doi: 10.1016/j.tcb.2016.04.006.



Necrosis and Necroptosis

Necrotic Cell Death, Shen H, Vandenabeele P (eds). Cell Death in Biology and Diseases vol. Springer Science+Business Media, 2014


Weinlich R, Oberst A, Beere HM, Green DR. Necroptosis in development, inflammation and disease. Nat Rev Mol Cell Biol 2017; 18: 127-136. doi: 10.1038/nrm.2016.149.


Krysko O, Aaes TL, Kagan VE et al. Necroptotic cell death in anti-cancer therapy. Immunol Rev 2017; 280: 207-219. doi: 10.1111/imr.12583.


Conrad M, Angeli JP, Vandenabeele P, Stockwell BR. Regulated necrosis: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 2016; 15: 348-366. doi: 10.1038/nrd.2015.6.


Wallach D, Kang TB, Dillon CP, Green DR. Programmed necrosis in inflammation: Toward identification of the effector molecules. Science 2016; 352: aaf2154. doi: 10.1126/science.aaf2154.


Moreno-Gonzalez G, Vandenabeele P, Krysko DV. Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine. Am J Respir Crit Care Med 2016; 194: 415-428. doi: 10.1164/rccm.201510-2106CI.


Dillon CP, Tummers B, Baran K, Green DR. Developmental checkpoints guarded by regulated necrosis. Cell Mol Life Sci 2016; 73: 2125-2136. doi: 10.1007/s00018-016-2188-z.


Pasparakis M, Vandenabeele P. Necroptosis and its role in inflammation. Nature 2015; 517: 311-320. doi: 10.1038/nature14191.


Jouan-Lanhouet S, Riquet F, Duprez L et al. Necroptosis, in vivo detection in experimental disease models. Semin Cell Dev Biol 2014; 35: 2-13. doi: 10.1016/j.semcdb.2014.08.010.


Vanden Berghe T, Linkermann A, Jouan-Lanhouet S et al. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol 2014; 15: 135-147. doi: 10.1038/nrm3737.


Vanden Berghe T, Hassannia B, Vandenabeele P. An outline of necrosome triggers. Cell Mol Life Sci 2016; 73: 2137-2152. doi: 10.1007/s00018-016-2189-y.



Lysosome-dependent cell death and cathepsins

Serrano-Puebla A, Boya P. Lysosomal membrane permeabilization as a cell death mechanism in cancer cells. Biochem Soc Trans 2018. doi: 10.1042/BST20170130.


Gomez-Sintes R, Ledesma MD, Boya P. Lysosomal cell death mechanisms in aging. Ageing Res Rev 2016; 32: 150-168. doi: 10.1016/j.arr.2016.02.009.


Serrano-Puebla A, Boya P. Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease. Ann N Y Acad Sci 2016; 1371: 30-44. doi: 10.1111/nyas.12966.


Aits S, Jaattela M, Nylandsted J. Methods for the quantification of lysosomal membrane permeabilization: a hallmark of lysosomal cell death. Methods Cell Biol 2015; 126: 261-285. doi: 10.1016/bs.mcb.2014.10.032.


Aits S, Jaattela M. Lysosomal cell death at a glance. J Cell Sci 2013; 126: 1905-1912. doi: 10.1242/jcs.091181.


Villamil Giraldo AM, Appelqvist H, Ederth T, Ollinger K. Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death. Biochem Soc Trans 2014; 42: 1460-1464. doi: 10.1042/BST20140145.


Repnik U, Stoka V, Turk V, Turk B. Lysosomes and lysosomal cathepsins in cell death. Biochimica et biophysica acta 2012; 1824: 22-33. doi: 10.1016/j.bbapap.2011.08.016.


Yamashima T. Can 'calpain-cathepsin hypothesis' explain Alzheimer neuronal death? Ageing Res Rev 2016; 32: 169-179. doi: 10.1016/j.arr.2016.05.008.




Fearnhead HO, Vandenabeele P, Vanden Berghe T. How do we fit ferroptosis in the family of regulated cell death? Cell Death Differ 2017; 24: 1991-1998. doi: 10.1038/cdd.2017.149.


Angeli JPF, Shah R, Pratt DA, Conrad M. Ferroptosis Inhibition: Mechanisms and Opportunities. Trends Pharmacol Sci 2017; 38: 489-498. doi: 10.1016/


Conlon M, Dixon SJ. Ferroptosis-like death in plant cells. Mol Cell Oncol 2017; 4: e1302906. doi: 10.1080/23723556.2017.1302906.


Dhingra R, Ravandi A, Kirshenbaum LA. Ferroptosis: Beating on Death's Door. Am J Physiol Heart Circ Physiol 2017. doi: 10.1152/ajpheart.00692.2017.


Kang R, Tang D. Autophagy and Ferroptosis - What's the Connection? Curr Pathobiol Rep 2017; 5: 153-159. doi: 10.1007/s40139-017-0139-5.


Lu B, Chen XB, Ying MD et al. The Role of Ferroptosis in Cancer Development and Treatment Response. Front Pharmacol 2017; 8: 992. doi: 10.3389/fphar.2017.00992.


Yu H, Guo P, Xie X et al. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. J Cell Mol Med 2017; 21: 648-657. doi: 10.1111/jcmm.13008.



Cell death and the immune system

Green DR. Cell death and the immune system: getting to how and why. Immunol Rev 2017; 277: 4-8. doi: 10.1111/imr.12553.


Daley SR, Teh C, Hu DY et al. Cell death and thymic tolerance. Immunol Rev 2017; 277: 9-20. doi: 10.1111/imr.12532.


Galluzzi L, Buque A, Kepp O et al. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol 2017; 17: 97-111. doi: 10.1038/nri.2016.107.



Cell death and cancer

Kreuzaler P, Watson CJ. Killing a cancer: what are the alternatives? Nat Rev Cancer 2012; 12: 411-424. doi: 10.1038/nrc3264.


Dillon CP, Green DR. Molecular Cell Biology of Apoptosis and Necroptosis in Cancer. Adv Exp Med Biol 2016; 930: 1-23. doi: 10.1007/978-3-319-39406-0_1.



Other aspects of cell death

Zhang Y, Chen X, Gueydan C, Han J. Plasma membrane changes during programmed cell deaths. Cell Res 2018; 28: 9-21. doi: 10.1038/cr.2017.133.


Green DR, Oguin TH, Martinez J. The clearance of dying cells: table for two. Cell Death Differ 2016; 23: 915-926. doi: 10.1038/cdd.2015.172.


Vanden Berghe T, Kaiser WJ, Bertrand MJ, Vandenabeele P. Molecular crosstalk between apoptosis, necroptosis, and survival signaling. Mol Cell Oncol 2015; 2: e975093. doi: 10.4161/23723556.2014.975093.


Kutscher LM, Shaham S. Non-apoptotic cell death in animal development. Cell Death Differ 2017; 24: 1326-1336. doi: 10.1038/cdd.2017.20.


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Sonja Aits
Lund University
Department of Experimental Medical Science
Cell Death and Lysosomes Group

221 84 Lund